WT3: Biological Soft Tissue Modeling
Work Task Leader:IOR
Main Contributors: INRIA, EPFL, SMI, CRS4
The goal of this WT is to develop a set of coherent rheological models for different selected tissues to be incorporated in the subsequent motion and visualisation tools, and to train researches on consistent application of these procedures. IOR develops a set of suitable experimental in vitro protocols, carries out passive characterization of soft tissues through mechanical testing on animal and human specimens, and rheological modeling (constitutive equations). Inter-subject variability is investigated, also in relation with age and gender. Collaborations take place in this WT for the developing of numerical simulation methods, with reference to experimental data (mechanical testing and extracted motion from images):
SMI trains and supplies IOR with muscle-specific knowledge: stress/ strain/ actuation relationships for contractile fibers, physiological/ kinematical data (from WT4), etc.
INRIA and CRS4 bring simplification methods with regards to tissue numerical simulation (models with different degrees of accuracy/complexity) or complementary acquisition techniques (e.g., laser scanner).
EPFL, responsible of developing the lower limb functional simulation framework (WT5), collaborates with IOR and INRIA for specifying the integration of tissues models and simulation methods.
The in vitro experiments are being designed based on agreed specifications with the relevant partners (INRIA, EPFL).
Major Research achievements
Design of appropriate protocols to store, prepare and test soft tissue specimens (tendons and ligaments);
Testing of a significant number of in vitro experiments on animal ligaments and tendons to study mechanical properties such as toe and linear elastic modulus;
Setup of novel 3D finite element model for simulation of ligaments able to integrate local anisotropy of oriented connective tissues as well as non-linear stress-strain responses;
Design of a study with a human cadaver knee to compare in silico with in vitro simulation results.